Principal Scientist, Lab Head, Integrative Neuroscience

Job title: Principal Scientist, Lab Head, Integrative Neuroscience

• Location: Cambridge, MA

About the Job

We are seeking a highly skilled and motivated scientist to lead a team focused on developing novel therapeutics, with a preference for RNA-based approaches for neurological disorders. In this role, you will drive biology to identify therapeutic targets and advance these targets through the discovery pipeline by leading multidisciplinary project teams. The ideal candidate will bring deep expertise in neurological disorders with a particular emphasis on neuropsychiatric, neurodevelopmental, and/or seizure-related disorders. Experience in RNA-based therapeutic modalities (siRNA and antisense oligonucleotides) is highly desirable.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main responsibilities:

• Lead drug development programs by managing timelines, defining key scientific questions, and ensuring team focus.

• Establish in vitro and in vivo models for molecule testing, biomarker discovery, and exploratory biology.

• Interrogate human datasets to identify novel pathways and targets, and collaborate with platform teams to apply cutting-edge genetic and genomic approaches for target credentialing.

• Contribute to programs using diverse therapeutic modalities, with an emphasis on gene knockdown/splicing technologies (e.g., siRNA and ASOs).

• Mentor team members, provide strategic and day-to-day guidance, and support laboratory execution.

• Perform laboratory experiments in partnership with team members.

• Implement AI into screening, experimental, and analysis workflows to accelerate discovery work.

• Collaborate effectively within matrixed, dynamic, and cross-functional teams across the Neurology therapeutic area, platform groups, and external partners.

• Build and maintain a robust external scientific network to support portfolio advancement, collaborations, licensing opportunities, and business development activities.

• Compile, present, and clearly communicate scientific progress to internal stakeholders, leadership, and external audiences.

• Publish scientific findings in peer-reviewed journals and present results at scientific conferences.

About You

Education:

• Ph.D. in neuroscience, neuropsychiatry, neurodevelopmental disorders, or a related field.

• A minimum of 3 years' experience in a drug development setting.

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Experience & Technical Skills:

• Prior drug development experience with RNA-based therapeutics. Knowledge of RNA conjugation, design, and delivery technologies.

Preferred Qualifications:

• Experience in neuropsychiatry and/or developmental disorders, including epilepsy.

• Understanding of ion channel biology and technical experience evaluating ion channel function.

• Ability to apply AI-based approaches to drug discovery.

• Demonstrated scientific creativity and productivity, evidenced by impactful publications in neurodevelopmental, neuropsychiatric, or epilepsy-related disorders.

• Deep expertise in cell-based disease models, including iPSC-derived, primary neuronal systems, and complex co-culture models.

• Strong understanding of in vivo pharmacology in rodents and/or non-human primates. Direct hands-on experience preferred.

• Ability to effectively define experimental goals and communicate scientific progress with colleagues and stakeholders from diverse backgrounds.

• Excellent analytical, presentation, and scientific writing skills.

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.

• Help improve the lives of millions of people globally by making drug development quicker and more effective.

• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.