Senior Principal Scientist I, Lab Head, Protein Engineering
剑桥, 麻薩諸塞州 Regular 发布于 Jul. 03, 2026 申请截止于 Oct. 02, 2026 Salary Range USD 148,500.00 - 214,500.00Job title: Senior Principal Scientist I, Lab Head, Protein Engineering
Location: Cambridge, MA
About the job
As Senior Principal Scientist I, Lab Head, Protein Engineering within our R&D team, you will lead a multidisciplinary team within the Protein Engineering group at our Cambridge Crossing research site. In this role, you will collaborate closely with two complementary labs within the Protein Engineering group — Structural Biology & Protein Design and Developability & Analytics — to advance our protein engineering capabilities and drive innovation across the group.
This leadership position offers a unique opportunity to shape the future of biologics engineering by combining deep experimental expertise with computational protein design, AI-enabled engineering, automation, and data-driven discovery. You will lead innovative antibody engineering strategies across diverse therapeutic modalities while working closely with other global LMR sites and LMR Digital Biologics. As Lab Head, you will help drive the evolution of Sanofi's next-generation antibody engineering platforms by integrating structure-guided design, high-throughput experimental technologies, protein language models, computational modeling, and AI/ML-enabled engineering approaches into biologics discovery workflows. You will represent Protein Engineering on multidisciplinary project teams, provide scientific leadership from early discovery through lead optimization, and contribute to the strategic direction of global engineering capabilities across LMR.
Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.
About Sanofi
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
Main Responsibilities
Lead protein engineering strategies for the design and optimization of multispecific antibodies, Fc-engineered molecules, fusion proteins, and other next-generation biologic modalities using experimental and computational approaches.
Design and execute antibody engineering campaigns including affinity maturation, molecular format engineering, developability optimization, and functional optimization through structure-guided, computational, and data-driven design.
Develop and continuously improve protein engineering platforms utilizing yeast and/or phage display, high-throughput screening, saturation mutagenesis, in silico-guided library design, linear expression cassette (LEC) workflows and automation.
Partner closely with LMR Digital Biologics and global Protein Engineering community to integrate computational modeling, protein language models, machine learning, generative AI approaches, and experimental validation into engineering strategies.
Identify and implement innovative technologies that enhance engineering efficiency, data quality, and scientific decision-making across biologics discovery.
Serve as the Protein Engineering representative on cross-functional project teams, collaborating with Therapeutic Areas and partner functions to define engineering strategies, coordinate project activities, and support milestone progression.
Lead, mentor, and develop a high-performing team of 5 scientists (scientists to principal scientists) while fostering scientific excellence, innovation, collaboration, and continuous learning.
Contribute to global LMR Antibody Engineering initiatives by establishing best practices, sharing technologies across research sites, developing platform capabilities, and driving scientific innovation throughout the organization.
Communicate scientific discoveries through presentations, publications, patents, and external scientific engagement.
About you
Ph.D. in Biochemistry, Molecular Biology, Biomedical Sciences, Bioengineering, Structural Biology, or a related discipline
9+ years of industry experience in biotechnology or pharmaceutical research.
Demonstrated scientific leadership in antibody and protein engineering, including multispecific antibodies, Fc engineering, affinity maturation, and molecular optimization.
Extensive experience with yeast and/or phage display technologies, antibody library design and construction, high-throughput screening, protein expression, purification, protein-protein interaction measurement and biophysical characterization.
Strong understanding of protein structure-function relationships and engineering strategies to optimize affinity, specificity, biological activity, developability, and manufacturability.
Experience leveraging Genedata Biologics or comparable digital platforms to support biologics discovery and engineering workflows.
Demonstrated ability to integrate computational design and AI-enabled approaches into protein engineering programs through collaboration with computational scientists and digital biology teams.
Proven experience leading multidisciplinary project teams and managing a team of scientists in a collaborative research environment.
Strong scientific communication skills with a demonstrated record of publications, patents, scientific presentations, and innovation.
Preferred Qualifications
Experience applying modern computational protein design approaches, including protein language models, ML-guided engineering, generative AI, and structure prediction tools to biologics discovery.
Experience with computational modeling software such as MOE, Rosetta, AlphaFold, PyMOL, or related platforms.
Experience developing automated and high-throughput protein engineering workflows.
Experience in additional protein engineering disciplines including glycoengineering, chemical conjugation, protein conjugates, or emerging biologic modalities.
Why Choose Us
Bring the miracles of science to life alongside a supportive, futurefocused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
Help improve the lives of millions of people globally by making drug development quicker and more effective.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
追寻 发展。探索 菲凡。
进步需要我们每个人的参与——不论其背景、地域、或职业，我们都有一个共同的愿望：创造奇迹。你也可以成为其中的一员。我们不断追求变革，拥抱新思想，探索我们所能提供的一切机会。让我们一起追求进步。共同发现非凡。
在赛诺菲，不分种族、肤色、血统、宗教、性别、国籍、性取向、年龄、公民身份、婚姻状况、残疾或性别认同，我们为所有人提供平等的机会。
观看 “在赛诺菲的一天” ，并在官网 (sanofi.com) 上查看赛诺菲的多元化、公平与包容倡议！
最终薪酬将根据已展现的经验、技能、工作地点和其他相关因素确定。员工可能有资格参与公司员工福利计划。
体验可能性
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Ama
Ama puts her project management techniques and ServiceNow knowledge to use to help advance Sanofi’s Digital Data operating model. Learn how our team connects data and AI to do what’s never been done before.
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Cambridge Crossing
We're bringing together 2,500 people from across our organization — R&D, Medical, Commercial and Global colleagues all working to realize the power of collaboration.
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Innovation in Action
Our flexible lab of the future will transform how we conduct research, while our innovation center will be fully integrated with existing R&D locations.
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Sanofi’s AI Centre of Excellence in Toronto
The Centre is focused on using leading technologies to develop world-class data and artificial intelligence (AI) products to create value for the health sector.
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Sanofi Canada's Philanthropic Efforts
By chasing the miracles of science to improve people’s lives, we surprise ourselves with what we can achieve. Our team is humbled by the impact our efforts make.
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Sustainable and Green
Our new facility was built to minimize the environmental impact — helping protect our planet and people. Using resources efficiently, we're providing greener, healthier workspaces.
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心怀梦想，成就一番事业
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我们的故事
我们关注每一个员工的声音。因为，我们的未来取决于所有员工的付出与努力。正因为他们的助力，我们才能追求远大的理想。
