Senior Principal Scientist, Lab Head, Immunomodulation / Cell Reprogramming

Job Title: Senior Principal Scientist, Lab Head, Immunomodulation - Cell Reprogramming

Location: Cambridge, MA

About the Job:

Sanofi Oncology is seeking a highly motivated individual with project leadership experience and deep knowledge in immuno-oncology. This individual will play a leading role in developing novel cell reprogramming and other therapies aimed at modifying the tumor microenvironment to treat cancer. The successful candidate will lead a team within the Immunomodulation & Cell Reprogramming Cluster where they are expected to support progression of existing programs, develop new projects, and contribute to the growth of the Immuno-Oncology portfolio. The position is based in Cambridge, Massachusetts, USA

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

Position Overview & Job Responsibilities:

• Lead and manage a team of scientists and cross-functional research teams, ensuring timelyprogression of projects from early concepts to first-in-human studies

• Mentor and develop team members, fostering scientific excellence, professional growth, and a lead-by-example culture

• Develop clear scientific strategies to support departmental goals and allocate resources to drive overall group performance

• Demonstrate innovation in research with deep understanding of clinical translation

• Apply scientific expertise to initiate, design, direct, and execute experiments while ensuring compliance with laboratory safety and documentation protocols

• Keep current with developments in basic research, clinical development, and the competitive landscape

• Publish and present findings in peer-reviewed journals and scientific conferences

About You:

Basic Qualifications:

• Ph.D. in Immunology, Immuno-Oncology, Cell Biology, Molecular Biology, or related discipline
• Minimum of 7 years of post-graduate research experience in the pharmaceutical, biotechnology, or related industry
• Deep knowledge in immunological mechanisms or tumor immunology
• Experience in cell therapy and/or tumor microenvironment research
• Hands-on experience in isolation and immune phenotyping of murine and human immune populations (e.g., cell sorting, flow cytometry), functional assessment of immune subsets (e.g., proliferation, cytotoxicity, cytokine/chemokine measurement), and murine tumor models including immune deficient and humanized mice
• Familiarity with techniques for genetically modifying immune cells to express novel transgenes
• Excellent organizational, communication, and presentation skills with the ability to work both collaboratively and independently

Why Choose Us:

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. 
• Help improve the lives of millions of people globally by making drug development quicker and more effective. 
• Achieve genuine work-life balance in a supportive R&D environment.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.