Post Doc for Protein De Novo Design / all genders

About the job

Our Team:

You will be a part of our global Biologics AI & Design team which is part of the Digital Biologics Platform (DBxP) within the Computational & AI Strategy organization. The team has an impressive track record of patents and publications in high-impact journals. As a global organization, we are dedicated to pushing the boundaries of computational and AI-based protein engineering to design innovative new medicines.

Main responsibilities:

• Explore alternative protein scaffolds as potential therapeutics.
• Contribute to the evolution of our computational platform for Antibody/NANOBODY® de novo design.
• Drive the development, training, and integration of novel deep and machine learning-based models for protein design & optimization.
• Collaborate with interdisciplinary screening and engineering teams to define strategies for experimental validation of computationally designed variants.
• Apply our computational workflows for protein design & optimization to design novel variants in the context of therapeutically relevant targets.
• Depending on your skill set, prior experience, and interests, there are opportunities to focus your contribution on specific aspects of the overall workflow (e.g. development of foundational AI-based models, evolution of de novo design workflows, application of de novo design capabilities for therapeutic applications,…).

About you

Education and professional Experience

• Ph. D. degree in the field of computational structural biology or computational life sciences (e.g. bioinformatics, computer science, biophysics, computational biology, data science (AI/ML) or life sciences with strong expertise in AI/ML & computational protein design).
• Experience in the implementation and application of ML-based methods for generative protein design.
• Strong publication track record in the field of protein design.

Soft skills

• Passion to collaborate with others, self-development with a focus on scientific know-how, and sharing knowledge.
• Ability to work both independently and in cross-functional international teams.

Technical skills

• Strong expertise in de novo design of functional proteins.
• Deep understanding on the physical principles that govern protein folding and protein complex formation.
• Deep expertise in AI/ML-based approaches for protein de novo design including application, training & fine-tuning of generative protein language models, diffusion- and flow matching approaches.
• Knowledge of antibody/NANOBODY® structure, function & engineering.
• Proficiency in Python and related libraries/software for de novo design (e.g. RFdiffusion, proteinMPNN, Rosetta, pyRosetta).
• Ability to develop, benchmark and apply predictive algorithms for protein engineering.
• Experience in handling, curating, and managing large biological data sets and data bases.
• Expertise in developing and maintaining data pipelines and automated data workflows.
• Comfortable working in cloud and high-performance computational environments.

Why choose us?

• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. 
• Help improve the lives of millions of people globally by making drug development quicker and more effective. 
• Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs. 
• Join a workplace where diversity, equity, and inclusion are at the core, with Employee Resource Groups and leadership programs that celebrate every voice.
• Bring the miracles of science to life alongside a supportive, future-focused team.

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