Senior Principal Scientist I

Job Title: Principal Scientist I

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. 

Sanofi Oncology Therapeutic Area is seeking an experienced computational biologist/bioinformatician to join our team with a focus on reprogramming the tumor microenvironment and immune system to treat tumors. This hands-on role will analyze patient datasets including bulk RNAseq, single cell RNAseq/CITEseq, and flow cytometry to identify cell types, signaling pathways and targets for overcoming immunosuppression.

In this role, you will work as an integral part of project teams in research and development to identify targets, understand compound activities, and develop and test actionable biomarker strategies for programs in immuno-oncology.  You will analyze patient genomic and transcriptomic data from internal studies, collaborations, and public sources to identify mechanisms and targets for novel immune-based, anti-cancer therapies. You will design, interpret, and analyze bulk and single cell NGS profiling experiments to characterize drug mechanism of action and identify biomarkers.  You will be responsible for presenting your work internally in project teams and larger-scale forums and externally in scientific publications and presentations. The ability to work both independently and in a team environment with colleagues across disciplines is critical. This position is based within the Immuno-Oncology Cell Therapy Cluster in Cambridge, MA.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?​

Main Responsibilities:

• Reports directly to Cluster Head with expectation the candidate will support multiple therapeutic programs and target discovery efforts

• Develop and execute computational strategies for disease characterization from datasets to propose targets and drug combinations

• Design and implement computational algorithms to analyze multi-omics, multi-modal, and high-content data with applications in target identification and engagement evaluation, patient stratification, response prediction, indication selection, and assay development

• Develop actionable biomarker plans (e.g. selection, PD, efficacy biomarkers) and support knowledge/technical transfer to Translational Medicine Unit as required for project progression

• Apply scientific expertise and judgement to initiate, design, direct and analyze experiments and studies in support of research programs

• Proactively engage with colleagues from Target, Disease & Systems Biology, other Oncology clusters and departments (R&D digital, etc) when relevant

About You

Basic Qualifications:

• Ph.D. in biology, statistics, biophysics, or bioinformatics related fields with emphasis on high-dimensional biological data analysis and a minimum of 5 years pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology or a related field

• Proven expertise in analyzing multi-modal, multi-dimensional, and large-scale biological data with a strong understanding of platforms used in research: flow cytometry, immunoassays, next generation sequencing (NGS), single cell sequencing and proteomics

• First-hand experience in using patient and preclinical NGS data to develop and support target selection or biomarker strategies

• Demonstrated expertise in Oncology or Immune-Oncology

• Demonstrated contributions to multi-disciplinary collaborations

• Experience analyzing and interpreting bulk and single cell transcriptomic and related datasets

• Proficiency in bioinformatic analysis using R or Python

• Familiarity with standard bioinformatic methods and reference datasets

• Ability to work independently and collaborate with other computational biologists across  departments in research and Translational Medicine Unit.

• Strong written and verbal communication skills

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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